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刘晓磊

发布日期:2020年07月22日 18:49    作者:     来源:     点击:

 

姓名

刘晓磊

性别

职称

讲师

电话

0531-82767825

邮箱

ism_liuxl@ujn.edu.cn

教育背景

2015-2019 博士 济南大学

2010-2013 硕士 济南大学

2004-2008 学士 山东师范大学

工作经历

2020.1.12-至今 济南大学 智能材料与工程研究院

2013.8-2015.8 康龙化成新药技术有限公司

2008.7-2010.6 山东潍坊润丰化工股份有限公司

主要研究方向

有机合成(天然产物、医药中间体、小分子探针)化工分离(三废处理、萃取工艺)

主持和承担科研项目

横向课题

9茚虫威及关键中间体合成工艺研发,承担,项目w2024193

8用于去除苯胺衍生物合成工艺中VOCs的催化剂的研制,承担,项目w2023056

7苯胺氧化法合成对苯二酚产业技术,承担,项目w2022224

6.(肿瘤手术)示踪剂的合成,承担,项目w2022172

5氟代碳酸乙烯酯、氯代碳酸乙烯酯、碳酸亚乙烯酯生产技术,承担,项目w2022022

4氟代碳酸乙烯酯、碳酸亚乙烯酯、聚丁二酸丁二醇酯生产技术,承担,项目w2022021

3济大-金凤凰产业技术研究院技术服务合同,承担,项目w2021311

2济南大学潍坊滨海产业技术研究院揭榜制项目,承担,授权项目编号1001405

1硅烷偶联剂NXT工艺实质开发承担项目编号w2020127

纵向课题

4利用平面多支分子构筑三维弱键体系及其固态堆积-场效应性能关系研究,国家自然科学基金青年基金,参与(第3位次),基金号:21202061

3超亲铀螯合吸附材料的设计、制备与性能研究,国家自然科学基金面上项目,参与(第3位次),基金号:21876062

2济南大学科技计划项目,主持,项目编号:XKY2066

1分子与纳米探针教育部重点实验室开放基金,主持,项目编号2020KLMNP03

教研课题

2教育部产学合作协同育人项目:新工科背景下化学工程与工艺专业应用型人才培养模式研究,承担,项目编号231007195313431

1有机化学课程群虚拟教研室,济南大学2022,参与;

代表性论文


16. Liu, X., Gong, C., Peng, X. Sun, G., Yao, W., Chu, Y., Zhang, Y. A Dibenzo-18-crown-6-based Symmetric Dual-coumarin Lead Ion Fluorescent Probe and Its Imaging in Living Cells. Chem. Res. Chin. Univ. (2024). https://doi.org/10.1007/s40242-024-4145-y

15. Xiaolei Liu, Chongzhen Gong, Liang Xue, Guoxin Sun, Yu Cui, Tianyong Zhang. Molecular glue -based highly sensitive fluorescent probe for the detection of ClO- and its imaging in living cells. J. Mol. Struc., 2025,1319(2),139575.

14. Xiaolei Liu, Yanjie Dua, Xiaofeng Yang, Xuchuan Jiang, Yu Cui, Guoxin Sun. Off-label use of molecular glue: 3-hydroxythalidomide derived fluorescent probe for selective detection of palladium based on Tsuji-Trost reaction. J. Photoch. Photobio., A -Chem, 2024, 449,115377.

13. Xin Wang, Mengjiao Zhang, Xiaolei Liu, Mingliang Lou, Gen Li, and Xiangbing Qi. Total Synthesis of Tetracyclic Spirooxindole Alkaloids via a Double Oxidative Rearrangement/Cyclization Cascade. Org. Lett. 2024,26, 824−828.

12. Lou Mingliang, Liu Xiaolei, Han Shoule, Bai Songlin, Qi Xiangbing. Total synthesis of (±)-3-demethoxyerythratidinone via Tf2O-promoted cascade reaction of enaminone. Chem. Commun., 2024,60, 3842-3845.

11. LIU Xiaolei, LU Yongqiang, YOU Qi, LIU Guohui, YAO Wei, HU Riming, YAN Jixian, CUI Yu, YANG Xiaofeng, SUN Guoxin, JIANG Xuchuan. A 3-Hydroxythalidomide-based Ratiometric Fluorescent Probe for the Detection of H2O2. Chem. J. Chinese Universities, 2022,43(6): 20220070.

10. Liu, X. L.; Lu, Y. Q.; Peng, X. J.; Sun, G.X. Asymmetric Total Syntheses of Strychnos Alkaloids via Selective Fischer Indolization. J. Org. Chem., 2022, 87, 5199-5212.

9. Liu, X. L.; Li, W. T.; Bai, S. L.; Cui, Y.; Sun, G. X. Off-label use of old drug: a 3-hydroxythalidomide-based fluorescent probe for the detection of hydrogen sulfide (H2S) and bioimaging in HeLa cells. Microchem. J., 2020, 158, 105144.

8. Liu, X. L.; Yang, Z.; Yang, X. F.; Cui, Y.; Sun, G. X. A 3-hydroxythalidomide-based fluorescent probe for detection of fluoride in water sample and bioimaging in living cells. Dyes Pigment. 2020, 174, 108108.

7. Liu, X. L.; Han, J. X.; Zhang, Y.; Yang, X. F.; Cui, Y.; Sun, G. X. A novel pH probe based on ratiometric fluorescent properties of dicyanomethylene-4H-chromene platform. Talanta, 2017, 174, 59-63.

6. Liu, X. L.; Sun, G. X.; Cai, X.C.; Yang, X. F.; Li, Y. X.; Sun, Z. M.; Cui, Y. Extraction of U(VI) with N,N,N′,N′-tetraoctyl diglycolamide from nitric acid solution. J. Radioanal. Nucl. Chem., 2015, 306, 549-553.

5. Liu, X. L.; Peng, X. J.; Yang, J. H.; Sun, G. X. The extraction behaviors of Nd(III), Sm(III), Gd(III), Dy(III), Er(III), Yb(III) with N,N’-dibutyl- N,N’-dioctyl-3-oxy-glutaramide from hydrochloric acid solution. IOP Conference Series: Earth and Environmental Science 2018, 170, 022118.

4. Gao, Y. D.; Yang, C.; Bai, S. L.; Liu, X. L.; Wu, Q. C.; Wang, J.; Jiang, C.; Qi, X. B. Visible-Light-Induced Nickel-Catalyzed Cross-Coupling with Alkylzirconocenes from Unactivated Alkenes. Chem, 2020, 6 (3), 675-688.

3. Yang, X. F.; Liu, X. L.; Li, Y. X.; et al. A differentially selective probe based on diketopyrrolopyrrole with fluorescence turn-on response to Fe3+, and dual-mode turn-on and ratiometric response to Au3+, and its application in living cell imaging. Biosens. Bioelectron., 2016, 80, 288-293.

2. Yang, X. F.; Zhang, Y.; Li, Y. X.; Liu, X. L.; et al. A diketopyrrolopyrrole-based fluorescence turn-on probe for the detection of Pb2+ in aqueous solution and living cells. RSC Adv., 2016, 6(57), 52004-52008.

1. Yang, X. F.; Li, Y. X.; Ding, Y. M.; Zhao, Z. S.; Zhang, Y.; Liu, X. L.; et al. Ratiometric & reversible fluorescent sensing of NaCN by an effective probe based on phenanthro[9,10-d]imidazole platform. Sens. Actuator, B: Chemical, 2017, 253, 478-487.

代表专利

6.刘晓磊; 李想; 蒋绪川等. 一种用于化工过程中的自动排水装置. 中国, ZL 2023 2 3050683.5.

5. 刘晓磊; 蒋绪川; 游淇等. 一种红光转光剂配体及其衍生物的连续性生产系统. 中国, ZL 2023 2 3014270.1.

4. 刘晓磊; 孙国新; 蒋绪川等. 一种负载型催化剂的制备方法及所得产品和应用. 中国, ZL 2023 1 0483060.2.

3. 刘晓磊; 孙国新; 蒋绪川等. 一种双亚胺型潜固剂及其制备方法和用途.中国, ZL 2022 1 0594027.2.

2. 刘晓磊; 孙国新; 蒋绪川等. 一种硼-10酸制备系统.中国, ZL 2022 2 2874223.3.

1. 刘晓磊; 杨小凤; 孙国新等. 一种基于苯并吡喃腈的可视化检测汞离子的探针的合成方法及应用. 中国, ZL 201610115917.5.


Contact information

Name

Xiaolei Liu

Gender

Male

Title

Lecturer

Telephone

0531-82767825

Email

ism_liuxl@ujn.edu.cn

Education

Background

2019  PhD      University of Jinan

2013  Master    University of Jinan

2008  Bachelor ---Shandong Normal University

Work Experience

2020.1-      - University of Jinan, Institute for Smart Materials & Engineering

2013.8-2015.8  Pharmaron Beijing Co., Ltd. (China)

2008.7-2010.6  Shandong Weifang Rainbow Chemical Co., Ltd.

Research Areas

Organic synthesis: Synthesis of natural products and pharmaceutical intermediates

Chemical extraction and separationExtraction and purification of rare earth ions

Research Projects

 

Teaching

 

Awards and Honours

 

Representative Publications

1. Liu, X. L.; Li, W. T.; Bai, S. L.; Cui, Y.; Sun, G. X. Off-label use of old drug: a 3-hydroxythalidomide-based fluorescent probe for the detection of hydrogen sulfide (H2S) and bioimaging in HeLa cells. Microchem. J. 2020, 158, 105144.

2. Liu, X. L.; Yang, Z.; Yang, X. F.; Cui, Y.; Sun, G. X. A 3-hydroxythalidomide-based fluorescent probe for detection of fluoride in water sample and bioimaging in living cells. Dyes Pigment. 2020, 174, 108108.

3. Liu, X. L.; Han, J. X.; Zhang, Y.; Yang, X. F.; Cui, Y.; Sun, G. X. A novel pH probe based on ratiometric fluorescent properties of dicyanomethylene-4H-chromene platform. Talanta 2017, 174, 59-63.

4. Liu, X. L.; Sun, G. X.; Cai, X.C.; Yang, X. F.; Li, Y. X.; Sun, Z. M.; Cui, Y. Extraction of U(VI) with N,N,N′,N′-tetraoctyl diglycolamide from nitric acid solution. J. Radioanal. Nucl. Chem. 2015, 306, 549-553.

5. Liu, X. L.; Peng, X. J.; Yang, J. H.; Sun, G. X. The extraction behaviors of Nd(III), Sm(III), Gd(III), Dy(III), Er(III), Yb(III) with N,N’-dibutyl- N,N’-dioctyl-3-oxy-glutaramide from hydrochloric acid solution. IOP Conference Series: Earth and Environmental Science 2018, 170, 022118.

6. Gao, Y. D.; Yang, C.; Bai, S. L.; Liu, X. L.; Wu, Q. C.; Wang, J.; Jiang, C.; Qi, X. B. Visible-Light-Induced Nickel-Catalyzed Cross-Coupling with Alkylzirconocenes from Unactivated Alkenes. Chem 2020, 6 (3), 675-688.

7. Yang, X. F.; Liu, X. L.; Li, Y. X.; et al. A differentially selective probe based on diketopyrrolopyrrole with fluorescence turn-on response to Fe3+, and dual-mode turn-on and ratiometric response to Au3+, and its application in living cell imaging. Biosensors and Bioelectronics, 2016, 80, 288-293.

8. Yang, X. F.; Zhang, Y.; Li, Y. X.; Liu, X. L.; et al. A diketopyrrolopyrrole-based fluorescence turn-on probe for the detection of Pb2+ in aqueous solution and living cells. RSC Advances, 2016, 6(57), 52004-52008.

9. Yang, X. F.; Li, Y. X.; Ding, Y. M.; Zhao, Z. S.; Zhang, Y.; Liu, X. L.; et al. Ratiometric & reversible fluorescent sensing of NaCN by an effective probe based on phenanthro[9,10-d]imidazole platform. Sensors and Actuators B: Chemical, 2017, 253, 478-487.

Representative Patents

1. Liu, X. L.; Yang, X. F.; Sun, G. X.; et al. Synthetic method and application of probe for visual detection of mercury ions based on benzopyran nitrile. ZL 201610115917.5.

2. Sun, G. X.; Liu, X. L.; Yang, X. F.; et al. Synthetic method of ratiometric pH fluorescent probe based on benzopyrannitrile and application. ZL 201610873157.4.

Others

 

 


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